Journal of Nanomedicine & Nanotechnology

Mitchell JC

Publications

• Research Article
  Design, Synthesis, Characterization and Toxicity Studies of Poly (N-Iso- Propylacrylamide-co-Lucifer Yellow) Particles for Drug Delivery Applications
  Author(s): Reham Mohsen, Alexander BD, Richardson SCW, Mitchell JC, Diab AA and Snowden MJ Reham Mohsen, Alexander BD, Richardson SCW, Mitchell JC, Diab AA and Snowden MJ
  
  A novel fluorescent temperature/pH responsive particle was designed, synthesized, characterised and tested for toxicity. Poly (N-iso-propylacrylamide-co-5%-lucifer yellow) (p(NIPAM-co-5% LY)) was prepared using a surfactant free emulsion polymerisation technique. The particles were negatively charged and were approximately 250 nm at 15°C. When the particles de-swell following an increase in temperature, a particle size around 100 nm is obtained. The toxicity of different concentrations of the new particles (p(NIPAM)-co-5% LY, as well as the 100% p(NIPAM) and the main monomer NIPAM was tested on two cell lines (Hela and Vero). The toxicity was tested in comparison to a positive control (dextran sugar) and a negative one (poly(ethylenimine)) (PEI). The results show that the two particles show cell viability over 80% (for both cell lines Hela and Vero) up to a concen.. View More»
  DOI: 10.4172/2157-7439.1000363

  Abstract PDF