Journal of Allergy & Therapy

Milton Arruda Martins

Publications

• Research Article
  Influence of Oral Tolerance on Lung Cytokines Expression and Oxidative Stress Activation in Guinea Pigs with Chronic Inflammation
  
  Author(s): Samantha Souza Possa, Renato Fraga Righetti, Viviane Christina Ruiz-Schütz, Adriane Sayuri Nakashima, Carla Máximo Prado, Edna Aparecida Leick, Milton Arruda Martins and Iolanda de Fátima Lopes Calvo Tibério Samantha Souza Possa, Renato Fraga Righetti, Viviane Christina Ruiz-Schütz, Adriane Sayuri Nakashima, Carla Máximo Prado, Edna Aparecida Leick, Milton Arruda Martins and Iolanda de Fátima Lopes Calvo Tibério
  
  Objective: We had previously demonstrated that oral induced tolerance attenuates lung tissue hyperresponsiveness, eosinophil inflammation and extracellular matrix remodelling in a model of chronic inflammation in guinea pigs. In the present study, we evaluated if these responses were associated to alterations on Th1/Th2 cell expression on airways and distal lung. Methods: Animals received seven inhalations of ovalbumin (1-5 mg/mL; OVA group) or saline (SAL group) during 4 wk. Oral tolerance (OT) was induced by offering ad libitum ovalbumin 2% in sterile drinking water starting with the 1st inhalation (OT1 group) or after the 4th (OT2 group). After the last inhalation, lungs were removed for the histological analysis using morphometry. We assessed IL-2, IL-4, IL-13, IFN-γ and iNOS both in airways and distal lung. Results: There was an increase in IL-2, IL-4, I.. View More»
  DOI: 10.4172/2155-6121.1000165

  Abstract