Journal of Vaccines & Vaccination

Michele Conversano

Publications

• Research Article
  Immunogenicity and Safety of Combined Tetanus, Reduced Diphtheria, Acellular Pertussis Vaccine when Co-Administered with Quadrivalent Meningococcal Conjugate and Human Papillomavirus Vaccines in Healthy Adolescents
  Author(s): Roberto Gasparini, William Johnston, Michele Conversano, Alan Garscadden, David Alexanderian, Noemi Giglioli, Sandra Percell, Linda Han and Igor Smolenov Roberto Gasparini, William Johnston, Michele Conversano, Alan Garscadden, David Alexanderian, Noemi Giglioli, Sandra Percell, Linda Han and Igor Smolenov
  
  Objective: Current United States immunization recommendations for adolescents include vaccines against tetanus, diphtheria and pertussis (Tdap), human papillomavirus (HPV), and Neisseria meningitidis serogroups A, C, W-135, and Y. In this Phase IV study, we primarily investigated the impact of concomitant administration of a quadrivalent meningococcal CRM197-conjugate vaccine (MenACWY-CRM) with Tdap and HPV vaccines, in terms of immunogenicity to Tdap antigens and overall reactogenicity. Methods: A total of 801 healthy adolescents aged 10-18 years were randomized to one of two groups to receive either MenACWY-CRM or a placebo, co-administered with Tdap and a quadrivalent HPV vaccine (HPV4). Antibody responses to the Tdap antigens, as well as to meningococcal serogroups A, C, W-135, and Y, were assessed at one month post-vaccination. Safety and adverse events were monitored throughout .. View More»
  DOI: 10.4172/2157-7560.1000231

  Abstract PDF