Journal of Nanomedicine & Nanotechnology

Michael R Hamblin

Publications

• Research Article
  Antimicrobial Photodynamic Therapy with Functionalized Fullerenes: Quantitative Structure-activity Relationships
  Author(s): Kazue Mizuno, Timur Zhiyentayev, Liyi Huang, Sarwat Khalil, Faria Nasim, George P Tegos, Hariprasad Gali, Ashlee Jahnke, Tim Wharton and Michael R HamblinKazue Mizuno, Timur Zhiyentayev, Liyi Huang, Sarwat Khalil, Faria Nasim, George P Tegos, Hariprasad Gali, Ashlee Jahnke, Tim Wharton and Michael R Hamblin
  
  Photosensitive dyes or photo sensitizers (PS) in combination with visible light and oxygen produce reactive oxygen species that kill cells in the process known as photodynamic therapy (PDT). Antimicrobial PDT employs PS that is selective for microbial cells and is a new treatment for infections. Most antimicrobial PS is based on tetrapyrrole or phenothiazinium structures that have been synthesized to carry quaternary cationic charges or basic amino groups. However we recently showed that cationic-substituted fullerene derivative were highly effective in killing a broad spectrum of microbial cells after illumination with white light. In the present report we compared a new group of synthetic fullerene derivatives that possessed either basic or quaternary amino groups as antimicrobial PS against Grampositive (Staphylococcus aureus), Gram-negative bacteria (Escherichia coli) and fungi (C.. View More»
  DOI: 10.4172/2157-7439.1000109

  Abstract PDF