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M.G. Siragusa
M.G. Siragusa
Italy
Publications
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Research Article
Galantamine Delivery on Buccal Mucosa: Permeation Enhancement and Design of Matrix Tablets
Author(s): V. De Caro, G. Giandalia, M.G. Siragusa, G. Campisi and L.I. GiannolaV. De Caro, G. Giandalia, M.G. Siragusa, G. Campisi and L.I. Giannola
The most important feature in transbuccal drug delivery is the low drug passage through the buccal mucosa. In our previous work we demonstrated the aptitude of Galantamine to penetrate the buccal tissue. The collected data suggested that Galantamine passively crosses the membrane, but the calculated Js and Kp values showed that the drug amount that crosses the membrane wasn’t sufficient to assure blood therapeutic level. So, in this study, ex vivo permeation tests, using porcine buccal mucosa, were performed in presence of physical or chemical enhancers. No significant differences in penetration rate were observed using chemical enhancers as sodium dehydrocholate, EDTA disodium salt and trisodium citrate dihydrate; while, Js and Kp were extensively affected by application of electric fields. Tablets, designed for Galantamine administration on buccal mucosa, were prepared by dire.. View More»
DOI: 10.4172/jbb.1000020