Journal of Bioequivalence & Bioavailability

Mendes GD

Publications

• Research Article
  Pharmacokinetic Evaluation of Administration of Losartan with Aspirin in Healthy Volunteers
  Author(s): Mendes GD, Ferreira PMF, Gagliano-Jucá T, Magalhães JCDA, Santos EM, Sampaio M and De Nucci GMendes GD, Ferreira PMF, Gagliano-Jucá T, Magalhães JCDA, Santos EM, Sampaio M and De Nucci G
  
  Losartan and aspirin are often used concomitantly in patients with heart failure, ischemic heart disease and hypertension. Objectives: To investigate whether aspirin co-administration affects losartan bioavailability. Methods: 1) Twenty-four healthy volunteers from both sexes were recruited. Volunteers received a single 50 mg losartan with or without a 81 mg aspirin tablet. Blood samples were obtained at 0.25, 0.5, 0.75, 1, 1.25, 1.5, 1.75, 2, 2.33, 2.67, 3, 3.5, 4, 4.5, 5, 6, 8, 10, 12 hour post-dosing. The concentrations of losartan were analyzed by LC-MSMS. Clearance (Cl) and T1/2 were used to evaluate a possible drug-drug interaction. Cmax and AUC0-8 were used to evaluate whether co-administration interferes on the bioavailability process. Results: From the losartan plasma concentrations vs. time curves the following pharmacokinetic parameters were obtained: ASC0-8 hours, AUCinf, .. View More»
  DOI: 10.4172/jbb.1000229

  Abstract PDF