Journal of Nanomedicine & Nanotechnology

Megan J Osmond-McLeod

Publications

• Research Article
  Surface Coatings Protect against the In vitro Toxicity of Zinc Oxide Nanoparticles in Human Hepatic Stellate Cells
  Author(s): Megan J Osmond-McLeod, Yalchin Oytam, Ronald IW Osmond, Fariborz Sobhanmanesh and Maxine J McCallMegan J Osmond-McLeod, Yalchin Oytam, Ronald IW Osmond, Fariborz Sobhanmanesh and Maxine J McCall
  
  Coatings applied to the surfaces of zinc oxide (ZnO) nanoparticles have been shown to decrease the capacity of uncoated nanoparticles to generate free radicals, as well as to reduce their solubility, and may be utilized in safetyby- design approaches to decrease ZnO nanoparticle toxicity. The liver is a target organ for ZnO nanoparticles, or ionic zinc released from ZnO nanoparticles, whether the route of entry is by dermal absorption, ingestion, injection or inhalation. Liver injury and fibrosis have been demonstrated in vivo in response to ZnO nanoparticle treatment, and cell injury has also been shown in vitro using immortalized hepatocyte cell lines. Despite their activation being a critical step for liver fibrosis, however, the response of human hepatic stellate cells (hHSCs) to ZnO nanoparticles has not yet been reported. Here, hHSCs were treated with four type.. View More»
  DOI: 10.4172/2157-7439.1000232

  Abstract PDF