Journal of Nanomedicine & Nanotechnology

Mato E

Publications

• Research Article
  Selective Antitumoral Effect of Sorafenib Loaded PLGA Nanoparticles Conjugated with Cetuximab on Undifferentiated/Anaplastic Thyroid Carcinoma Cells
  Author(s): Mato E, Puras G, Bell O, Agirre M, Hernández RM, Igartua M, Moreno R, Gonzalez G, Alberto de Leiva Hidalgo and Jose Luis Pedraz Mato E, Puras G, Bell O, Agirre M, Hernández RM, Igartua M, Moreno R, Gonzalez G, Alberto de Leiva Hidalgo and Jose Luis Pedraz
  
  Drug targeting represents a challenging approach with promising potential to circumvent some problems associated with many toxic effects of antineoplastics drugs. The objective of the present study was to develop PLGA nanoparticles surface modified with cetuximab to deliver in a targeted fashion sorafenib into undifferentiated/anaplastic thyroid carcinoma cell line as an efficient in vitro model Sorafenib loaded nanoparticles were obtained by the single emulsion evaporation method and characterized in terms of size (252 nm), charge (-14.6 mV), morphology (spherical), drug entrapment efficiency (58%) and in vitro drug release. Resulted nanoparticles were surface conjugated with monoclonal antibody cetuximab by EDC/Sulfo-NHS cross linking chemistry, without affecting significantly to their physicochemical properties. 51% of the cetuximab was incorporated into .. View More»
  DOI: 10.4172/2157-7439.1000281

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