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Mathieu Vinken
Mathieu Vinken
Department of Toxicology Faculty of Medicine and Pharmacy,
Vrije Universiteit Brussel Laarbeeklaan 103 B-1090 Brussels
Belgium
Publications
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Editorial
Mathieu Vinken's Work on the Role of Connexin-related in Hepatic Homeostasis and its Relevance for Liver-based In vitro Modelling
Author(s): Mathieu VinkenMathieu Vinken
Direct intercellular communication mediated by gap junctions constitutes a major regulatory platform in the control of hepatic homeostasis. Hepatocellular gap junctions are composed of two hemichannels of adjacent cells which are built up by connexin proteins, in casu Cx32. Dr. Mathieu Vinken, postdoctoral research fellow at the Department of Toxicology of the Free University Brussels-Belgium, was one of the first investigators to demonstrate that hepatic connexin expression is controlled by epigenetic mechanisms. In particular, he found that inhibitors of histone deacetylase enzymes enhance Cx32 production and gap junction activity in cultures of primary hepatocytes, a finding that is of importance for liver-based in vitro modelling. Dr. Mathieu Vinken’s recent work is focussed on the elucidation of the role of connexin proteins and their channels in the hepatocyte life cycle. .. View More»
DOI: 10.4172/2153-2435.1000101e