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Masako Shimada
Masako Shimada
Thier 10, 50 Blossom Street, Boston, MA 02114,
Tanzania
Publications
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Research Article
MicroRNA–Mediated Regulation of Apoptosis in Osteosarcoma
Author(s): Masako ShimadaMasako Shimada
Osteosarcoma is the most common primary bone cancer that predominantly affects children and young adolescents. Despite the progress in understanding the pathophysiology of osteosarcoma, it remains gravely influencing mobility and mortality of those young patients. A balance between cell proliferation and apoptosis is often dysregulated in cancer; tumor cells often show accelerated proliferation and reduced apoptosis, resulting in uncontrolled cancer cell growth. The recent discovery of microRNAs has added an exciting new layer of research interest in the fields of medical research in general including cancer. miRNAs are a class of 22~25 nucleotide non-coding RNAs that play a critical role in epigenetic modification of physiological functions of their target genes. Various pathway-specific and tumor-specific miRNAs have been identified and the mechanisms, by which they regulate patholo.. View More»
DOI: 10.4172/2157-2518.S6-001