Marta Muraca
Italy
Research Article
Eosinophilic Esophagitis and Ige-Mediated Allergy in Children: Specific
Ige by Component-Based-Allergen Microarray
Author(s): Francesca Rea, Leila Emma D’Urbano, Rosa Luciano, Marta Muraca, Luigi Dall’Oglio, Giovanni Cavagni and Paola De Angelis
Francesca Rea, Leila Emma D’Urbano, Rosa Luciano, Marta Muraca, Luigi Dall’Oglio, Giovanni Cavagni and Paola De Angelis
Background: Atopy is prevalent in eosinophilic esophagitis (EoE) but the relative role of airborn and food allergens in the etiopathogenesis is still incompletely understood; allergic immediate and delayed reactions are involved.
Objective: We characterized the sIgE profile by a component-based allergen microarray with highly purified allergens in EoE in comparison with traditional sIgE assay and we evaluated a possible correlation between clinical features and sIgE results.
Methods: In 30 consecutive patients diagnosed with EoE, three diagnostic tests were performed: skin prick test (SPT), ImmunoCAP ï€ sIgE and an allergen component microarray chip called ImmunoCAP ISAC. The ISAC chips cover 103 recombinant or purified allergen molecules including food, airborn and cross-reactive allergens.
Results: Out of th.. View More»
DOI:
10.4172/2155-6121.1000180