Journal of Allergy & Therapy

Marsella R

Publications

• Research Article
  Clinical and Immunologic Effects of Allergen-Specific Sublingual Immunotherapy in a Canine Model of Atopic Dermatitis: A Double Blind, Randomized, Controlled Study
  Author(s): Marsella R and Ahrens KMarsella R and Ahrens K
  
  Sublingual Allergen Specific Immunotherapy (SLIT) has been advocated for the treatment for allergies. Controlled studies are difficult to perform in humans due to the variety of allergies, diet, and allergenic exposure. This prospective, randomized, controlled study evaluated clinical and immunological effects of one year of SLIT using an experimental model of atopic dermatitis in dogs. Eighteen Beagles, sensitized to dust mites, timothy grass and ragweed were divided into control (n=6, vehicle) and active (n=12, 3 allergens) groups. Allergen challenge and scoring of clinical signs was done before and at the end of one year of SLIT. Blood was drawn at baseline, 4,8, and 12 months of SLIT and 2 months after stopping SLIT to measure allergen-specific IgE, IL-10, and TGF-beta. After 12 months of SLIT, ANOVA showed significant decrease of clinical scores for both groups (p<.000.. View More»
  DOI: 10.4172/2155-6121.1000157

  Abstract PDF