Journal of Nanomedicine & Nanotechnology

Markus Drechsler

Publications

• Research Article
  Production, Physico-Chemical Characterization and Biodistribution Studies of Lipid Nanoparticles
  Author(s): Elisabetta Esposito, Helga Eveline De Vries, Susanne M.A. van der Pol, Federico Boschi, Laura Calderan, Silvia Mannucci, Markus Drechsler, Catia Contado, Rita Cortesi and Claudio Nastruzzi Elisabetta Esposito, Helga Eveline De Vries, Susanne M.A. van der Pol, Federico Boschi, Laura Calderan, Silvia Mannucci, Markus Drechsler, Catia Contado, Rita Cortesi and Claudio Nastruzzi
  
  This study describes the preparation, characterization, in vitro uptake and in vivo biodistribution in mice of solid lipid nanoparticles and nanostructured lipid carriers. The effect of nanoparticle lipid matrix, presence of fluorescent and functionalization by polysorbate 80 on dimensional distribution and morphology have been studied by sedimentation field flow fractionation, photon correlation spectroscopy and cryogenic transmission electron microscopy. The complementary use of different techniques demonstrated that lipid matrix composition, presence of fluorescent dye and polysorbate 80 functionalization have little effect on nanoparticle morphology and size distribution. Uptake of fluorescent nanoparticles was determined in vitro by human brain endothelial cells, showing that nanoparticles treated by polysorb.. View More»
  DOI: 10.4172/2157-7439.1000256

  Abstract PDF