Journal of Bacteriology & Parasitology

Marina Moraes Mourão

Publications

• Commentary
  RNA Interference and Nonspecific Controls in Parasitic Helminths
  Author(s): Marina Moraes Mourão* and Sandra Grossi Gava Marina Moraes Mourão* and Sandra Grossi Gava
  
  Despite of the remarkable success of RNA interference (RNAi) application in the free-living nematode Caenorhabditis elegans, the exploitation of this powerful technique to helminths parasites with complex life-cycle has been a challenge for parasitologists. It has proved to be effective only for certain parasite species and specific target genes. To date, RNAi is the only methodology available for reverse genetics in trematodes and combined to rescue studies (such heterologous complementation) have been the only alternative to genetic manipulation in nematodes and helminths parasites, thus this subject is of great interest to the scientific community involved in the field. The RNAi technique is widely used to assess gene function in helminths parasites, in order to elucidate their role in parasite development, mechanisms of drug resistance, and validate therapeutic targets for .. View More»
  DOI: 10.4172/2155-9597.1000325

  Abstract PDF