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Marie-Hélène Gaumond
Marie-Hélène Gaumond
Canada
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Review Article
The Potential Use of Nanoparticles for Noggin siRNA Delivery to Accelerate Bone Formation in Distraction Osteogenesis
Author(s): Ana Cristina Ferreira Bassit, Pierre Moffatt, Marie-Hélène Gaumond and Reggie Hamdy Ana Cristina Ferreira Bassit, Pierre Moffatt, Marie-Hélène Gaumond and Reggie Hamdy
In bone research and orthopedics, RNA-interference (RNAi) and nanotechnology can be applied to a vast array of conditions where bone formation needs to be enhanced, providing new options to treat old problems, from osteoporosis and bone tumors to nonunion and critical size defects. The need for new therapeutic tools to improve bone regeneration is evident, mainly in more complex orthopedic surgical procedures. Distraction Osteogenesis (DO) is a unique surgical technique that stimulates bone formation, most frequently used to promote limb lengthening through slow and progressive distraction after osteotomy. The great challenge is to reduce the consolidation phase and prevent the complications related to the maintenance of the external fixator for a long period. Bone Morphogenetic Proteins (BMPs) have been used as potent osteoinductive growth factors, b.. View More»
DOI: 10.4172/2157-7439.1000257