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Maria Papagianni
Maria Papagianni
Department of Hygiene and Technology of Food of Animal Origin, School of Veterinary Medicine, Aristotle University of Thessaloniki. Thessaloniki 54006,
Greece
Publications
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Review Article
Methodologies for Scale-down of Microbial Bioprocesses
Author(s): Maria PapagianniMaria Papagianni
Much research has been done on bioreactor hydrodynamics and their interactions with various microbial cell mechanisms and several methodologies have been proposed in order to resolve scale-up problems. Among them is the approach of scale-down and regime analysis. Regime analysis at production scale has to define the rate-limiting mechanisms of the process and identify the ruling regime. Such an analysis, based on characteristic times, can give valuable information for scale translation and optimization of bioprocesses. An efficient scale-down bioreactor has to create conditions that will be representative for the conditions occurring at large scale. Miniaturised bioreactor (MBR) systems may serve as scale-down tools especially in early-stage process operations. In later stages, e.g. optimization of process conditions and operations, only scaleable apparatus can be applied successfully.. View More»
DOI: 10.4172/1948-5948.S5-001