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Margarida Lima
Margarida Lima
Hospital de Santo António , Centro Hospitalar do Porto,
Rua D. Manuel II, s/n 4099-001 Porto
Portugal
Publications
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Review Article
Aggressive Mature Natural Killer Cell Neoplasms: From EBV-Infection to Disease Etiopathogeny
Author(s): Margarida LimaMargarida Lima
Mature Natural Killer (NK) cell neoplasms are rare tumors with higher prevalence in Asia, Central and South America, which are related to Epstein Barr Virus (EBV) infection. Nature killer /T cell lymphoma, nasal type, presents as a localized or generalized destructive tumor, affecting the nose, the upper aero digestive tract or any organ or tissue, whereas aggressive NK-cell leukemia manifests as a systemic disease that preferentially affects the bone marrow, the spleen and the liver, and rapidly evolve to multiorgan failure resulting in death. Both NK-cell neoplasms arise as a consequence of the inability of the immune system to control EBV infection and of the transforming potential of multiple EBV gene products. Chronic active EBV infection and EBV-related lymphoproliferative disorders of NK-cells are predisposing conditions. The tumor NK-cells do express an EBV infection type II l.. View More»
DOI: 10.4172/2155-9864.1000193