Marcellino Monda
Italy
Research Article
Sera of Overweight Patients Alter Adipogenesis and Osteogenesis of Bone
Marrow Mesenchymal Stromal Cells, a Phenomenon that also Persists in
Weight Loss Individuals
Author(s): Angela Ferone, Giovanni Messina, Nicola Alessio, Stefania Capasso, Marilena Cipollaro, Marcellino Monda, Gianfranco Peluso, Umberto Galderisi and Giovanni Di Bernardo
Angela Ferone, Giovanni Messina, Nicola Alessio, Stefania Capasso, Marilena Cipollaro, Marcellino Monda, Gianfranco Peluso, Umberto Galderisi and Giovanni Di Bernardo
Background: Overweight and obesity represents a complex interaction of genetics, diet, metabolism, and physical activity. Abnormal or excessive body fat accumulation increases the risk of pathologies, such as heart disease, diabetes, and high blood pressure.
Methods and results: In a previous paper, we investigated the influence of overweight individuals’ sera on in vitro biology of mesenchymal stromal cells, which contain a subpopulation of multipotent stem cells. This report extended the study by evaluating effects of sera collected from weight loss patients on stromal cultures.
Results showed that an increase in fat mass induces physiological changes that negatively impact on stromal stem cell adipogenesis and osteogenesis with a bias toward adipocyte differentiation. This phenomenon occur.. View More»
DOI:
10.4172/2157-7633.1000347