Mara Ferrara
Via de Crecchio, 80138 Naples
Italy
Case Report
Postsplenectomy Thromboembolic Risk in Children with Hematologic Disorders: Case Report
Author(s): Mara Ferrara, Fabrizia Bertocco, Dolores Ferrara and Laura CapozziMara Ferrara, Fabrizia Bertocco, Dolores Ferrara and Laura Capozzi
Objective and Importance: We have evaluated retrospectively in splenectomized hematologic patients by 10 year follow-up the incidence of thromboembolic events (VTE) in relationship not only with thrombocytosis but also with other possible risk factors, particularly anemia and some genetic mutations. Clinical presentation: Fifty children of both sexes with Hereditary Spherocytosis (HS), Piruvate Kinase Deficit (PK), Congenital Dyserythropoiesis II (CDII), Chronic Idiopathic Thrombocytopenic Purpura (cITP), β thalassemia intermedia (TI), splenectomized at 12.8 ± 6.2 years and untransfused or not transfused in the last 5 years were followed. Four patients with iron deficiency anemia had, on follow-up, deep venous thrombosis (DVT) during pregnancy (1 HS and 1 cITP) or after blood losses (2 PK deficits). Two patients with mild chronic anemia affected by CDII and TI respectively.. View More»