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Mao-Yuan Chen
Mao-Yuan Chen
No. 7, Chung Shan South Road, Taipei
People's Republic of China
Publications
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Research Article
Detection of Persistent Human Parvovirus 4 Infection in Patients with Antiphospholipid Syndrome
Author(s): Mao-Yuan Chen, Chien-Ching Hung and Kuang-Lun Lee Mao-Yuan Chen, Chien-Ching Hung and Kuang-Lun Lee
Parvovirus 4 (PARV4) is one of the emerging human parvoviruses discovered recently. PARV4 has long-lasting persistence in tissues after primary infection, but persistent PARV4 viremia has yet to be effectively detected in humans. In the present work, longitudinal serum samples from eleven patients with antiphospholipid syndrome were tested by nested polymerase chain reaction for the presence of PARV4 DNA. In one patient, PARV4 4 DNA was detected in all longitudinal serum samples collected over a period of 119 months. In addition, PARV4 DNA was present in two or more longitudinal serum samples from seven other patients. Two possible explanations are a persistent infection with intermittent low viral load below detection limit and a recurrent reactivation of latent infection. In conclusion, to our knowledge, this is the first direct evidence of detection of persistent PARV4 infection. P.. View More»
DOI: 10.4172/2327-5073.1000281