Journal of Microbial & Biochemical Technology

Manoj K Shrivash

Publications

• Research Article
  Attenuation of Pathogenicity in Candida albicans by Application of Polyphenols
  Author(s): Manoj K Shrivash, Sonali Mishra, Sneh Lata Panwar, Shabnam Sircaik, Jyoti Pandey and Krishna Misra1Manoj K Shrivash, Sonali Mishra, Sneh Lata Panwar, Shabnam Sircaik, Jyoti Pandey and Krishna Misra1
  
  Candida albicans is one of the most pathogenic and opportunistic class of fungi. Its emergence disturbs the human biome and can create serious damage in immunocompromised conditions. Hyphal growth and biofilm formation are mainly the core factors leading to progression of pathogenicity in C. albicans. The drug resistance towards azoles has created a demand of new novel pharmacologically active compounds. Although there are several pathways and factors known for causing pathogenicity there is none single connected pathway known for the whole mechanism such as SAP5, N-myrstyltransferase, Erg11 and Efg1 proteins. In the present study we have focussed on all the pathways and sorted major factors contributing in more than one pathways. The plant based polyphenols that have been studied here are non-toxic and more efficient as compared to the marketed azoles. These selected polyphenols were.. View More»
  DOI: 10.4172/1948-5948.1000392

  Abstract PDF