Pharmaceutica Analytica Acta

Manoj K. Saini

Publications

• Short Communication
  Dielectric Spectroscopy in Ibuprofen-Dioxane Mixture
  Author(s): Manoj K. Saini Manoj K. Saini
  
  In recent years, the dielectric study of amorphous pharmaceuticals has made a considerable effort towards correlating the molecular mobility with their physical and chemical stability. The molecular mobility of amorphous materials is affected by temperature, additives (such as water) and specific interactions (such as Hydrogen bond). Therefore, to understand the physicochemical instability of amorphous materials, nature of their molecular mobility needs to comprehend. In this order, the Dielectric and Calorimetric measurements were performed on a mixture of ibuprofen and 1,4-dioxane. The dielectric spectroscopy reveals two relaxation processes, (designated as αD, and α) in the supercooled region. The spectral shape of αD and α process can be explained satisfactorily throughout the frequency range using Havriliak-Negami (HN) shape function. The α.. View More»
  DOI: 10.4172/2153-2435.1000572

  Abstract PDF