Journal of Blood Disorders & Transfusion

Manash Saha

Publications

• Research Article
  Estimation of Iron Overload-Implications of its Non-linear Correlation
  Author(s): Prosanto Kumar Chowdhury, Manash Saha, Sujit Karpurkayastha, Dhritidipa Chowdhury and Jena RK Prosanto Kumar Chowdhury, Manash Saha, Sujit Karpurkayastha, Dhritidipa Chowdhury and Jena RK
  
  Thalassaemias and haemoglobinopathies contribute the highest number of cases, as far as single gene disorders are concerned, where blood transfusion and iron chelation remain the mainstays of therapy. Depending upon the requirement of transfusion, thalassaemias have been classified into two categories: 1) Transfusion dependent, 2) Non-transfusion dependent. Non-transfusion dependent thalassaemia patients, contrary to previous belief, suffer from iron overload. If this iron is estimated by the level of ferritin in serum, it does not linearly correlate to hepatic and/or cardiac iron. It was noted during our study that serum ferritin levels up to 300 ng/ml correlated with hepatic iron load of up to 3 mg/g of DLT almost linearly, within +0.5 SD of mean. There were a few patients in whom the serum ferritin level compared to the corresponding hepatic iron content (as mea.. View More»
  DOI: 10.4172/2155-9864.1000360

  Abstract PDF