Journal of Pharmacogenomics & Pharmacoproteomics

Malika Mehalhal

Publications

• Research Article
  Factor 8 Gene Mutations and Risk of Inhibitor Development in Hemophilia A Algerian Patients
  Author(s): Faouzia Zemani-Fodil, Meriem Abdi, Mostefa Fodil, Meriem Samia Aberkane, Naima Mesli, Mohamed Belazaar, Malika Mehalhal, Yasmina Rahal, Hadj Touhami, Nadhira Saidi-Mehtar and Abdallah BoudjemaFaouzia Zemani-Fodil, Meriem Abdi, Mostefa Fodil, Meriem Samia Aberkane, Naima Mesli, Mohamed Belazaar, Malika Mehalhal, Yasmina Rahal, Hadj Touhami, Nadhira Saidi-Mehtar and Abdallah Boudjema
  
  Background: Neutralizing inhibitors development toward factor VIII is one of the most challenging complications in the treatment of hemophilia A. Several studies have suggested that genetic factors influence the development of factor VIII inhibitors such as ethnicity, family history, mutations in the factor 8 gene and in genes of the immune system. The aim of the present study was to analyze the relationship between inhibitor development and F8 gene mutation types in a sample of hemophiliac patients from West Algeria. Methods: To study the molecular predisposition for inhibitor development, we genotyped 24 hemophiliac patients with and without inhibitors. A conventional Fisher’s exact test was used for statistical analysis. A p-value<0.05 was considered to indicate statistical significance. Results: A total of.. View More»
  DOI: 10.4172/2153-0645.1000124

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