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Malik SA
Malik SA
India
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Research Article
NADPH: Quinone Oxidoreductase 1 (NQO1609C>T) Polymorphism and Gastric Cancer Risk: A Meta-Analysis
Author(s): Manzoor Ahmad Malik, Haq S, Yetoo DM, Baba RA, Nissar S, Gull A, Malik SA and Shah ZA Manzoor Ahmad Malik, Haq S, Yetoo DM, Baba RA, Nissar S, Gull A, Malik SA and Shah ZA
Evidence is increasingly emerging about multiple roles for the NAD (P) H quinine oxidoreductase 1 (NQO1) enzyme in gastric cancer (GC). The NQO1609C>T (Pro187Ser) null polymorphism of the NQO1 gene contributes significantly to the variation in enzymatic activity across different populations. NQO1609C>T polymorphism was thoroughly investigated with respect to gastric cancer susceptibility. The results were inconsistent partly due to low sample sizes. The aim of the present work was to perform a meta-analysis to assess association for gastric cancer. Present meta-analysis involved eligible studies including 722 cases and 853 controls. Present metaanalysis found a statistically significant association between the variant T allele and overall cancer risk in the worldwide population (for the TT vs CC; co-dominant model, OR=1.568; 95%CI=1.096-2.244; P=0.014). At allele level, NQO1609C.. View More»
DOI: 10.4172/2157-2518.1000249