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Maldonado Bonilla LD
Maldonado Bonilla LD
Institute of Genetics,
Mexico
Publications
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Research Article
The 5´ → 3´ Exoribonuclease 2 as a Potential Target for Developing Fungicides to Control the Panama Disease
Author(s): Maldonado Bonilla LD and Calderón-Oropeza MAMaldonado Bonilla LD and Calderón-Oropeza MA
An outbreak of Fusarium oxysporum f. sp. cubense Tropical Race 4 is currently threatening the global production of bananas. Due to the clonal nature of commercial banana plants, selecting resistant cultivars does not seem feasible; therefore, alternative approaches to crop protection must be developed. The 5´ → 3´ exoribonuclease XRN2/RAT1 is involved in 5´ → 3´ RNA decay. Fungal studies with XRN2 and conditional mutants have illustrated the crucial role of this enzyme, suggesting XRN2 should be considered as target to searching for novel inhibitors that might be used as fungicides to control Panama disease. Our in silico analysis of Tropical Race 4 XRN2 (FocTR4XRN2) revealed characteristic features of 5´ → 3´ exoribonuclease such as the catalytic domain that recognizes 5´-monophosphorylated RNA and catalyses the processed cleav.. View More»
DOI: 10.4172/2157-7471.1000453