Biochemistry & Analytical Biochemistry

Mahbouba Frih

Publications

• Research Article
  Correlations between Peripheral Trans Fatty Acids, Lipid Peroxidation Markers and Cognition in Dementia
  Author(s): Amira Zarrouk, Imed Cheraif, Samia Hadj-Ahmed, Wafa Chaabane, Sonia Hammami, Meryam Debbabi, Mahbouba Frih, Olivier Rouaud, Thibault Moreau, Gérard Lizard and Mohamed HammamiAmira Zarrouk, Imed Cheraif, Samia Hadj-Ahmed, Wafa Chaabane, Sonia Hammami, Meryam Debbabi, Mahbouba Frih, Olivier Rouaud, Thibault Moreau, Gérard Lizard and Mohamed Hammami
  
  Relationships between alterations in lipid metabolism, oxidative stress and dementia are widely suspected. In order to determine the impact of trans fatty acids (TFA) on oxidative stress and lipid peroxidation in demented patients, plasma and red blood cells (RBCs) were collected from patients diagnosed with Alzheimer’s diseases (AD) or vascular dementia, and from an age-matched healthy control group of elderly individuals. Fatty acid profiles were established by gas chromatography on matched plasma and RBCs. Lipid peroxidation biomarkers (malondialdehyde (MDA) and conjugated dienes (CD)) were analyzed using spectrophotometric methods. The severity of dementia was evaluated with the Mini-Mental State Examination (MMSE). An accumulation of MDA and CD and of several TFA was observed in the plasma and RBCs of demented patients. In the plasma and RBCs, positive correlations were fou.. View More»
  DOI: 10.4172/2161-1009.1000206

  Abstract PDF