Biochemistry & Analytical Biochemistry

Magadi Gopalakrishna Sridhar

Publications

• Research Article
  Protective Effect of Soy Isoflavones (from Glycine max) on Adipose Tissue Oxidative Stress and Inflammatory Response in an Experimental Model of Post-menopausal Obesity: The Molecular Mechanisms
  Author(s): Sankar Panneerselvam, Rajaa Muthu Packirisamy, Zachariah Bobby and Magadi Gopalakrishna Sridhar Sankar Panneerselvam, Rajaa Muthu Packirisamy, Zachariah Bobby and Magadi Gopalakrishna Sridhar
  
  Obesity, adiposity mediated oxidative stress and inflammatory response has been identified to have an etiological origin for most of the complications associated with ageing populace. However, there are limited studies addressing the metabolic role of adipose tissue in the pathobiology of postmenopausal complications with respect to oxidative stress and inflammation. Numerous studies have reported the beneficial effects of soy isoflavones on postmenopausal complications; however, its efficacy these complications in postmenopausal model of obesity remain unclear. In the present study we found that the both ovariectomy and high fat diet (30 per cent fat) in isolation and in combination developed adipose tissue oxidative stress as evidenced by the reduced level of total antioxidant status (TAS) in association with elevated levels of adipose tissue malondialdehyde (MDA) and MDA/TAS ratio... View More»
  DOI: 10.4172/2161-1009.1000266

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