Journal of Carcinogenesis & Mutagenesis

Luis O González

Publications

• Review Article
  Clinical Relevance of Matrix Metalloproteases and their Inhibitors in Breast Cancer
  Author(s): Noemí Eiró, Belen Fernandez-Garcia, Luis O González and Francisco J VizosoNoemí Eiró, Belen Fernandez-Garcia, Luis O González and Francisco J Vizoso
  
  Degradation of the stromal connective tissue and basement membrane components are key elements in tumor invasion and metastasis. Some components, particularly the interstitial collagens, are very resistant to proteolytic attacks and can be degraded by specific proteinases like Matrix Metalloproteinases (MMPs). MMPs can also impact on tumor cell behavior in vivo as a consequence of their ability to cleave growth factors, cell surface receptors, cell adhesion molecules, or chemokines/cytokines, and for stimulating angiogenesis. Different molecular expression profiles of MMPs and their inhibitors (TIMPs) have been associated with the main steps in breast cancer progression, such as creating a potential invasive phenotype in Ductal Carcinoma in situ (DCIS), favoring the hematogenous dissemination, and enabling the metastatic progression across the axillary lymphatic system. These associat.. View More»
  DOI: 10.4172/2157-2518.S13-004

  Abstract PDF