Journal of Bioequivalence & Bioavailability

Luciana Oliveira

Publications

• Research Article
  Evaluation of the Pharmacokinetic Interaction between Candesartan Cilexetil and Felodipine
  Author(s): Eduardo Abib Junior, Luciana Fernandes Duarte, Luciana Oliveira and Fabio Proença BarrosEduardo Abib Junior, Luciana Fernandes Duarte, Luciana Oliveira and Fabio Proença Barros
  
  The study was performed to evaluate the pharmacokinetic interaction of test formulation of candesartan 16 mg tablet and felodipine extended release 5 mg tablet together in a combination package, comparing with the fasting period intake of commercial formulations of both Atacand® 16 mg tablet and Splendil® extended release 5 mg tablet (Test formulation and reference formulation from AstraZeneca, Brazil) in 36 volunteers of both sexes. The study was conducted open with randomized three period crossover design and a one week wash out period. The candesartan and felodipine were analyzed by LC-MS-MS. The mean ratio of parameters C max and AUC 0-t and 90% confidence intervals of correspondents were calculated to determine the pharmacokinetic interaction. Geometric mean of candesartan exposure together in a combination package felodipine individual percent ratio was 102.51% AUC 0-t a.. View More»
  DOI: 10.4172/jbb.1000049

  Abstract PDF