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Lucia Disch
Lucia Disch
Switzerland
Publications
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Research Article
Sustained Release for St. John?s Wort: A Rational Idea?
Author(s): Lucia Disch, Kristina Forsch, Beate Siewert, Jürgen Drewe and Gert Fricker Lucia Disch, Kristina Forsch, Beate Siewert, Jürgen Drewe and Gert Fricker
Purpose: Aim of this study was to evaluate St. John’s wort (SJW) extract for its suitability to be formulated in a sustained release dosage form using Ze 117 as example extract. Methods: Hypericin as marker for naphtodianthrones and quercetin as marker for contained flavonoids in Ze 117 were evaluated for solubility through shake flask method and for in vitro permeability through Caco-2 monolayers. Furthermore, different intestinal segments were screened for absorption capacity of markers using an in situ rat model. Results: Over a physiological pH range, naphthodianthrones exhibited pH-dependent solubility profiles with best solubility at pH 6.8. In contrast, solubility of flavonoids was pH-independent. In Caco-2 monolayer system, low permeation was evident for naphthodianthrone hypericin, while the flavonoid quer.. View More»
DOI: 10.4172/jbb.1000363