Journal of Nanomedicine & Nanotechnology

Lua Thi Minh Dang

Publications

• Research Article
  Anti-Tumor Activity of Docetaxel PLGA-PEG Nanoparticles with a Novel Anti-HER2 scFv
  Author(s): Duong Thi Thuy Le, Lua Thi Minh Dang, Nhung Thi My Hoang, Huyen Thi La, Huyen Thi Minh Nguyen and Huan Quang Le Duong Thi Thuy Le, Lua Thi Minh Dang, Nhung Thi My Hoang, Huyen Thi La, Huyen Thi Minh Nguyen and Huan Quang Le
  
  Background: In this study, we developed pegylated (poly(D,L-lactide-co-glycolide) (PLGA-PEG) nanoparticles for loading docetaxel and improving active target in cancer cells because it’s advantages over other nanocarriers such as excellent biocompatibility, biodegradability and mechanical strength and these nanoparticles were conjugated with molecules of a novel anti-HER2 single chain fragment (scFv) by a simple carbodiimide modified method. ScFvs have potential advantages over whole antibodies such as more rapid tumor penetration and clearance. In addition, to investigate cellular uptake of targeted nanocarriers, many studies had performed by linking with fluorescent factors but in this study 6-histidine-tag fused with novel anti-HER2 scFv antibodies can be used to purify protein and study binding activity and cellula.. View More»
  DOI: 10.4172/2157-7439.1000267

  Abstract PDF