Journal of Carcinogenesis & Mutagenesis

Leonardo M Porchia

Publications

• Research Article
  Common BRCA1 and BRCA2 Mutations among Latin American Breast Cancer Subjects: A Meta-Analysis
  Author(s): Leonardo M Porchia, M Elba González Mejia, Luis Calderilla-Barbosa, Nirvana I Ordaz Diaz, Fabiola Islas Lugo, José Oldak, Rossana C Zepeda and Gisela AguirreLeonardo M Porchia, M Elba González Mejia, Luis Calderilla-Barbosa, Nirvana I Ordaz Diaz, Fabiola Islas Lugo, José Oldak, Rossana C Zepeda and Gisela Aguirre
  
  Background: Many BRCA1 and BRCA2 mutations have been characterized in breast cancer subjects; however, the overall prevalence in Latin American remains elusive. The aim of the study was to determine the prevalence of common BRCA1 and BRCA2 mutations in Latin American breast cancer subjects. Methods: Pubmed, EBSCO, and OVID databases, and study bibliographies were systematically searched for observational studies that examined for mutations in BRCA1 and BRCA2 until March 2015. The pooled prevalence was obtained using the inverse double arcsine square root method. Publication bias was assessed by Begg and Mazumdar’s test and the Egger’s test. The sensitivity was determined by reevaluation of the pooled estimate after removal of one study. Results: Out of 294 retrieved studies, 32 studies met the inclusion criteria (n=9938 subjects). Twenty-nine BRCA1 and .. View More»
  DOI: 10.4172/2157-2518.1000228

  Abstract PDF