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Lenore L. Dai
Lenore L. Dai
School for Engineering of Matter, Transport and Energy,
Tempe, AZ 85287
Tanzania
Publications
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Research Article
Thermo-Responsive Core-Shell Composite Nanoparticles Synthesized via One-Step Pickering Emulsion Polymerization for Controlled Drug Delivery
Author(s): Sriya Sanyal, Huang-Chiao Huang, Kaushal Rege and Lenore L. DaiSriya Sanyal, Huang-Chiao Huang, Kaushal Rege and Lenore L. Dai
Purpose: The focus of this work is to develop a unique drug delivery vehicle which can be taken up by cancer cells and can release the loaded drug. Methods: Core-shell composite nanoparticles have been prepared by one-step Pickering emulsion polymerization with a nonionic initiator, using silica as the sole stabilizer. More importantly, the Pickering emulsion polymerization is applied to synthesize polystyrene/poly(N-isopropylacrylamide) (PNIPAAm)-silica core-shell nanoparticles with N-isopropylacrylamide incorporated into the core as a co-monomer. Results: The composite nanoparticles are temperature sensitive and can be taken up by human prostate cancer (PC3 and PC3-PSMA) cells. An anticancer agent 17-(Allylamino)-17-demethoxygeldanamycin (17-AAG) has been loaded into the polymeric cores during formation of the nanoparticles and drug release has been successfully observed at elev.. View More»
DOI: 10.4172/2157-7439.1000126