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Leekha A
Leekha A
India
Publications
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Research Article
Elucidation of Glutathione-S-transferase Activity Induced by Pectin- Cisplatin Nano-conjugates for Optimization of New Therapeutic Strategies
Author(s): Anita Kamra Verma and Leekha AAnita Kamra Verma and Leekha A
Despite tremendous efforts to search novel drugs and treatments, cancer continues to be a major health hazard. Modulation of cellular responses to platinating agents has important clinical implications as they are still heavily prescribed against various cancers. First line chemotherapeutic drug used for treating solid tumors, displays dose limiting nephrotoxicity. Natural products are being sought in order to improve the anticancer efficacy of cisplatin. Pectin, a plant polysaccharide have reported strong anti-oxidant and anti-cancer properties. In our study, Pectin- Cisplatin nanoconjugates in size range of (200 ± 20 nm) were synthesized and assessed for their anti-cancer and renoprotective role. The cytotoxicity of Pec-cis nanoconjugates and cis per se was assessed and co-related with the Glutathione-s-transferase level in both, in-vitro (B-16/F-.. View More»
DOI: 10.4172/2157-7439.1000391