Journal of Nanomedicine & Nanotechnology

Lee Josephson

Publications

• Research Article
  Development of Secreted Protein and Acidic and Rich in Cysteine (SPARC) Targeted Nanoparticles for the Prognostic Molecular Imaging of Metastatic Prostate Cancer
  Author(s): Stephanie Thomas, Peter Waterman, Suelin Chen, Brett Marinelli, Marc Seaman, Scott Rodig, Robert W. Ross, Lee Josephson, Ralph Weissleder and Kimberly A. KellyStephanie Thomas, Peter Waterman, Suelin Chen, Brett Marinelli, Marc Seaman, Scott Rodig, Robert W. Ross, Lee Josephson, Ralph Weissleder and Kimberly A. Kelly
  
  Prostate cancer is the most commonly diagnosed non-skin malignancy in the United States and presents with a wide range of aggressiveness from extremely slow-growing to highly aggressive. There is a clinical need to determine the metastatic potential of the primary tumor to design the most appropriate treatment plan ranging from watchful waiting to more aggressive, invasive surgical treatments. In this study we have developed a nanoparticle based imaging agent that targets SPARC (Secreted Protein Acidic Rich in Cysteine), a molecular marker of prostate cancer metastatic potential. Previous studies by this group used phage display to identify a peptide with high binding affinity and specificity for SPARC. In this study, the SPARC-targeted peptide sequence was used to design a biomaterial with improved pharmacokinetic properties by attaching it to a biocompatible nanoparticle that is als.. View More»
  DOI: 10.4172/2157-7439.1000112

  Abstract PDF