Biology and Medicine

Leandro Fernandes

Publications

• Research Article
  Maternal Vitamin B Deficiency and Epigenetic Changes of Genes Involved in the Alzheimer’ s Disease Pathogenesis
  Author(s): Vanessa Cavalcante da Silva, Leandro Fernandes, Ana Luiza Dias Abdo Agamme, Eduardo Jun Haseyama, Maria Tereza Cartaxo Muniz and Vânia D’AlmeidaVanessa Cavalcante da Silva, Leandro Fernandes, Ana Luiza Dias Abdo Agamme, Eduardo Jun Haseyama, Maria Tereza Cartaxo Muniz and Vânia D’Almeida
  
  Alzheimer's disease (AD) is characterized by progressive neurodegenerative impairment of the central nervous system and is the most prevalent form of dementia. Considering the influence of maternal nutrition on fetal programming, which consequences usually come later in life, we investigated whether maternal vitamin B deficiency during early development alters the offspring expression of genes related to AD etiopathogenesis. Mice dams were submitted to experimental diet one month before and during pregnancy or pregnancy/lactation and, after birth, their offspring were distributed into three groups: control “CT”, deficient pregnancy “DP” and deficient pregnancy and lactation “DPL”. At postnatal day (PND) 0, a significant decrease of App in females (p=0.007) and App and Bace1 in males (p=0.030 and p=0.040, respectively) was observed when compared to C.. View More»
  DOI: 10.4172/0974-8369.1000393

  Abstract PDF