Laura A Cox
Australia
Research Article
Bioinformatics and Evolution of Vertebrate Pancreatic Lipase and Related Proteins and Genes
Author(s): Roger S Holmes and Laura A CoxRoger S Holmes and Laura A Cox
Background: Pancreatic lipase (PTL) functions in the presence of colipase in the hydrolysis of emulsified fats in the small intestine following secretion from the pancreas. Pancreatic lipase related protein 1 (PLR1) is also found in pancreatic secretions and may perform a regulatory role in lipolysis; PLR2 catalyses pancreatic triglyceride and galactolipase reactions while PLR3 may serve a related but unknown lipase function. Comparative PTL, PLR1, PLR2 and PLR3 amino acid sequences and structures and gene locations and sequences were examined using data from several vertebrate genome projects.
Methods: Sequence alignments and conserved predicted secondary and tertiary structures were studied and key amino acid residues and domains identified based on previous reports on human and pig PTL. Comparative analyses of vertebrate PTL-like genes we.. View More»
DOI:
10.4172/2153-0602.1000111