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Laila R. Ismail
Laila R. Ismail
Egypt
Publications
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Research Article
In Vitro and In Vivo Anticancer Activity of the Fruit Peels of Solanum melongena L. against Hepatocellular Carcinoma
Author(s): Marawan M Shabana, Maha M Salama, Shahira M Ezzat and Laila R. IsmailMarawan M Shabana, Maha M Salama, Shahira M Ezzat and Laila R. Ismail
Background: The fruit peels’ of Solanum melongena L. which is a common vegetable in Egypt, were investigated for biologically active metabolites in an approach to find any medicinal benefits from such waste products.Methods: The Methanol Extract of the Peels (MEP) was subjected to fractionation and purification for the isolation of its major constituents. Identification of the compounds was carried out on the basis of physico-chemical properties and spectral analysis (1H NMR, 13C NMR, COSY and HMBC). The MEP together with the isolated compounds were tested against five human cancer cell lines representing the most common types of cancer in Egypt: colon cancer cell line (HCT116), larynx cancer cell line (HEP2), breast cancer cell line (MCF7), cervix cancer cell line (HELA) and liver cancer cell line (HEPG2). MEP was tested in v.. View More»
DOI: 10.4172/2157-2518.1000149