Journal of Nanomedicine & Nanotechnology

Lacava ZGM

Publications

• Research Article
  High Efficacy in Hyperthermia-associated with Polyphosphate Magnetic Nanoparticles for Oral Cancer Treatment
  Author(s): Candido NM, Calmon MF, Taboga SR, Bonilha JL, dos Santos MC, Lima ECD, Sousa CRS, Lacava ZGM and Paula RahalCandido NM, Calmon MF, Taboga SR, Bonilha JL, dos Santos MC, Lima ECD, Sousa CRS, Lacava ZGM and Paula Rahal
  
  Nanotherapy applied to cancer treatment is constantly evolving, and new approaches to current techniques, such as magnetohyperthermia, are being implemented to solve and minimize the limitations of conventional therapeutic strategies. The purpose of this study was to investigate the action of polyphosphate-coated maghemite nanoparticles (MNPs) on oral squamous cell carcinoma. Human oral cancer cells (UM-SCC14A) were incubated with MNPs at various concentrations and subjected to cell proliferation tests (MTT), apoptosis assays and transmission electron image analysis. Viability and apoptotic events were time and dose dependent. These in vitro tests showed that at the intermediate concentration tested there is no significant toxicity, as confirmed by transmission electron microscopy. For this reason this MNPs concentration was chosen for the subsequent in vivo tests. Oral tumor inductio.. View More»
  DOI: 10.4172/2157-7439.1000205

  Abstract PDF