Journal of Nanomedicine & Nanotechnology

Kwok-Fai So

Publications

• Research Article
  A Self-assembling Nanomaterial Reduces Acute Brain Injury and Enhances Functional Recovery in a Rat Model of Hypertensive Intracerebral Hemorrhage
  Author(s): Lynn Yan-Hua Sang, Yu-Xiang Liang, Kwok-Fai So, Gilberto Ka-Kit Leung, Rutledge G Ellis-Behnke and Raymond Tak-Fai CheungLynn Yan-Hua Sang, Yu-Xiang Liang, Kwok-Fai So, Gilberto Ka-Kit Leung, Rutledge G Ellis-Behnke and Raymond Tak-Fai Cheung
  
  Intracerebral hemorrhage (ICH) carries a high morbidity and mortality rate. High systolic blood pressure promotes hematoma growth. A self-assembling peptide (SAP) can achieve immediate hemostasis via formation of a SAP nanofiber scaffold (SAPNS). A minimally invasive aspiration of hematoma plus local delivery of SAPNS may lead to decompression of brain tissue and prevent hematoma growth. In a rat model of renovascular hypertension, experimental ICH was induced by a local injection of bacterial collagenase IV into the left basal ganglia. At 3.5 hours after induction of ICH, stereotactic clot aspiration or sham aspiration was performed manually. Following hematoma aspiration, an intrastriatal injection of 1% SAP, saline or sham injection was performed. Hematoma volume and brain swelling were quantified at 24 hours after ICH. Brain sections were immuno histochemically processed f.. View More»
  DOI: 10.4172/2157-7439.1000224

  Abstract PDF