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Krutika K Sawant
Krutika K Sawant
Kalabhavan,
Vadodara 390001, Gujarat
India
Publications
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Research Article
Optimization of Galantamine Loaded Bovine Serum Albumin Nanoparticles by Quality by Design and Its Preliminary Characterizations
Author(s): Aditi Poddar and Krutika K SawantAditi Poddar and Krutika K Sawant
Alzheimer’s disease is a progressive neurodegenerative disorder having a severe socio-economical and medical burden all over the world. The objective of this work was to develop nanoparticulate drug delivery system for Galantamine Hydrobromide (GAL) with the aid of Quality by Design (QbD) for intranasal administration to improve its targeting to brain. Bovine Serum Albumin (BSA) nanoparticles were prepared by desolvation process. Quality Target Profile and Critical Quality Attribute was set, proper risk identification and risk analysis was conducted using the Failure Mode and Effect Analysis. After proper risk assessment, optimization of the formulation was done using the Box-Behnken Design. Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) were conducted. The characterization was done by studying the entrapment efficiency, particle size, zeta potential, transm.. View More»
DOI: 10.4172/2157-7439.1000459