Journal of Stem Cell Research & Therapy

Kovanecz I

Publications

• Research Article
  Muscle Derived Stem Cells Stimulate Muscle Myofiber Repair and Counteract Fat Infiltration in a Diabetic Mouse Model of Critical Limb Ischemia
  Author(s): Tsao J, Kovanecz I, Awadalla N, Gelfand R, Sinha-Hikim I, White RA and Gonzalez-Cadavid NF Tsao J, Kovanecz I, Awadalla N, Gelfand R, Sinha-Hikim I, White RA and Gonzalez-Cadavid NF
  
  Background: Critical Limb Ischemia (CLI) affects patients with Type 2 Diabetes (T2D) and obesity, with high risk of amputation and post-surgical mortality, and no effective medical treatment. Stem cell therapy, mainly with bone marrow mesenchymal, adipose derived, endothelial, hematopoietic, and umbilical cord stem cells, is promising in CLI mouse and rat models and is in clinical trials. Their general focus is on angiogenic repair, with no reports on the alleviation of necrosis, lipofibrosis, and myofiber regeneration in the ischemic muscle, or the use of Muscle Derived Stem Cells (MDSC) alone or in combination with pharmacological adjuvants, in the context of CLI in T2D. Methods: Using a T2D mouse model of CLI induced by severe unilateral femoral artery ligation, we tested: a) the repair efficacy of MDSC implanted into the ischemic muscle .. View More»
  DOI: 10.4172/2157-7633.1000370

  Abstract PDF