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Konstanze Plaschke
Konstanze Plaschke
Experimental Anesthesiology, Medical Faculty of the University of Heidelberg,
Germany
Publications
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Research Article
Surgery under Propofol Anesthesia Induced Behavioral Changes Associated With Increased Cerebral Apoptosis in Rats
Author(s): Konstanze Plaschke, Julia Schneider and Jürgen Kopitz Konstanze Plaschke, Julia Schneider and Jürgen Kopitz
It is not known whether prolonged propofol anesthesia and/or surgery are responsible for postoperative cerebral deterioration, including Alzheimer-like histological changes, apoptosis and cognitive dysfunction. Therefore, the aim of the present study was to use partial liver resection as a surgical rat model in middle-aged rats in order to distinguish postoperative cerebral changes brain from those in rats after propofol anesthesia without surgery. In this randomized, controlled study, behavioral changes were investigated in n=36 rats (12- to 14-month-old) using the hole board test system and Morris water maze. Cerebral glycogen synthase kinase-3ß (GSK-3ß) and tau protein were analyzed using ELISA technique. Cerebral amyloid was determined using congo red staining with subsequent fluorescence analysis. Apoptosis in rat brain was analyzed using TUNEL test and casp.. View More»
DOI: 10.4172/2167-0889.1000136