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Koichiro Iohara
Koichiro Iohara
Japan
Publications
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Research Article
Identification of Thyrotropin-Releasing Hormone (TRH)-Degrading Enzyme as a Biomarker for Dental Pulp Tissue
Author(s): Tsubasa Yamamoto,Masashi Murakami,Ryo Ishizaka,Koichiro Iohara,Kenichi Kurita,Misako Nakashima* Tsubasa Yamamoto,Masashi Murakami,Ryo Ishizaka,Koichiro Iohara,Kenichi Kurita,Misako Nakashima*
Regeneration of dental pulp after pulpectomy was accomplished recently by autologous transplantation of dental pulp stem/ progenitor cells into the root canal. The identical patterns of qualitative and quantitative protein and mRNA expression in the regenerated pulp and normal pulp demonstrated complete pulp regeneration. The lack of tissue specific markers in the dental pulp is a major challenge in dental regenerative medicine. In order to identify specific markers in dental pulp we undertook a comparison of the gene expression profile of the dental pulp with that of periodontal ligament and gingiva. This systematic investigation identified thyrotropinreleasing hormone (TRH)-degrading enzyme (DE) as a marker of dental pulp. Expression of TRH-DE mRNA in human dental pulp was higher than that in any other tissue except brain as analyzed by real time RT-PCR. Induction of neural cells en.. View More»
DOI: 10.4172/2161-1122.1000114