Journal of Vaccines & Vaccination

Kimiko Hagihara

Publications

• Research
  Changes of Antibody Associated with Cell-Mediated Immunity in College Students During Two Years after Rubella Vaccination
  Author(s): Kihei Terada, Kimiko Hagihara, Yuhei Tanaka, Hideto Teranishi, Tomohiro Oishi, Ippei Miyata, Satoko Ogita, Naoki Ohno and Kazunobu OuchiKihei Terada, Kimiko Hagihara, Yuhei Tanaka, Hideto Teranishi, Tomohiro Oishi, Ippei Miyata, Satoko Ogita, Naoki Ohno and Kazunobu Ouchi
  
  Objective: This study measured cell-mediated immunity (CMI) and serum antibody levels against rubella to clarify antibody changes associated with CMI during 2 years after vaccination. Methods: The study subjects were 64 college students in two groups: 38 subjects who (having exhibited hemagglutination-inhibition (HI) anti-rubella antibody titers of ≤ 1:16) had been vaccinated with a rubella vaccine 2 years previously (Group 1); and 26 subjects who (having exhibited HI titers ≥ 1:32) had not been vaccinated 2 years previously (Group 2). All students were tested for IgG antibody levels (by enzyme-linked immunosorbent assay) and CMI (by interferon-γ (IFN-γ release assay). Results: The IgG antibody and IFN-γ values decreased significantly in Group 1 during the 2 years postvaccination, while antibody .. View More»
  DOI: 10.4172/2157-7560.1000376

  Abstract PDF