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Kheireddine El-Boubbou
Kheireddine El-Boubbou
King Abdulaziz Medical City, National Guard Health Affairs, Riyadh 11481
Saudi Arabia
Publications
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Research Article
Magnetic Nanocarriers Enhance Drug Delivery Selectively to Human Leukemic Cells
Author(s): Kheireddine El-Boubbou, Rizwan Ali, Hassan M Bahhari and Mohamed BoudjelalKheireddine El-Boubbou, Rizwan Ali, Hassan M Bahhari and Mohamed Boudjelal
Selective drug delivery to human leukemia cells using a nanoparticulate chemotherapeutic formulation is hugely needed. In this work, we report the development of a magnetic nanocarrier made of PVP-stabilized magnetic iron oxide nanoparticles (PMNP) loaded with the anticancer drug Doxorubicin (Dox) as a promising selective drug carrier to different types of human leukemia and normal cells. Our results revealed that while the unloaded MNPs were not potent to any of the cells, Dox@PMNPs showed significant toxicities, effectively killing the different leukemia cells, albeit at different inhibitory concentrations. Interestingly and superior to free Dox, Dox@PMNPs showed enhanced and significant inhibition towards the human monocytic THP-1 cells compared to human promyelocytic leukemia cells HL-60 (2-fold enhanced cytotoxicities), with the least potency towards the normal peripheral blood m.. View More»
DOI: 10.4172/2165-8064.1000441