Journal of Nanomedicine & Nanotechnology

Kevin R Bobbitt

Publications

• Research Article
  Cellular Uptake and Radio-sensitization Effect of Small Gold Nanoparticles in MCF-7 Breast Cancer Cells
  Author(s): Branislava Janic, Fangchao Liu, Kevin R Bobbitt, Stephen L Brown, Indrin J Chetty, Guangzhao Mao, Benjamin Movsas and Ning WenBranislava Janic, Fangchao Liu, Kevin R Bobbitt, Stephen L Brown, Indrin J Chetty, Guangzhao Mao, Benjamin Movsas and Ning Wen
  
  Gold nanoparticles (AuNPs) are shown to increase cancer cells sensitization to ionizing radiation. Theoretical models predicted that due to the differences in absorption coefficient between gold and soft tissue, maximum sensitization can be achieved at kilovoltage (kV), with minimum to no effect at megavoltage (MV) range, which was indeed demonstrated by previous research on AuNPs radio-sensitization with kV radiation. However, AuNPs effect at MV energies is still not clear. Radio-sensitization depends on AuNPs’ internalization by cancer cells that is in turn affected by AuNPs size. The purpose of this study was to explore, in vitro, radio sensitization potential of AuNPs of 4 and 14 nm size with clinically relevant MV, as well as kV photons in MCF7 breast cancer cell line. We investigated the differences in cellular uptake and intracellular localiza.. View More»
  DOI: 10.4172/2157-7439.1000499

  Abstract PDF