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Kazumi Fujioka
Kazumi Fujioka
Division of Laboratory Medicine, Department of Pathology and Microbiology,
Itabashi-ku, Tokyo
Japan
Publications
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Research Article
Presentations of Clinical, Ultrasonographic and Pathological Features of Nodular Fasciitis from an Established Cytogenetic Viewpoint: Review of the Case Series
Author(s): Kazumi Fujioka Kazumi Fujioka
Even though nodular fasciitis (NF) is benign and self-limited, the clinical, ultrasonographyic and pathological presentations have been described as mimicking sarcoma. We have reported that proliferative findings on both US and histology may be caused by the cytogenetic nature of NF. When the lesion showed the proliferative findings of the margin on both US and pathology, accompanied with clinical rapid growth and self-limited course, NF should be strongly suggested as one of the skin tumors as previously described. NF has been cytogenetically considered as a novel model of transient neoplasia induced by MYH9-USP6 gene fusion. It has been suggested that strong overexpression of USP6 under MYH9 promoter appears to drive tumorigenesis. A clear association between NF and a recurrent genetic abnormality had been established in fluorescence in-situ hybridization .. View More»
DOI: 10.4172/2157-2518.1000326