Journal of Allergy & Therapy

Kazuhito Asano

Publications

• Research Article
  Influence of Histamine H1 Receptor Antagonists on Thioredoxin Production In vitro and In vivo
  Author(s): Tomomi Mizuyoshi, Masayo Asano, Atsuko Furuta, Kazuhito Asano and Hitome Kobayashi Tomomi Mizuyoshi, Masayo Asano, Atsuko Furuta, Kazuhito Asano and Hitome Kobayashi
  
  Background: Thioredoxin (TRX), a 12-kDa oxidoreductase enzyme, is well known to be a redox-active protein that regulates reactive oxidative metabolism. TRX is also accepted to be a protein with anti-inflammatory effects and reported to attenuate the development of allergic airway inflammatory diseases such as allergic rhinitis (AR) and asthma. Although histamine H1 receptor antagonists are frequently used for the treatment of AR, the influence of the agents on TRX production is not well understood. In the present study, we examined the influence of fexofenadine (FEX), cetirizine (CT), and levocetirizine (LCT), which are classified into histamine H1 receptor antagonists, on TRX production in vitro and in vivo. Methods: Macrophages derived from THP-1 cells (1 × 105 cells/ml) were cultured with 50 μM H2O2 in combination with/without th.. View More»
  DOI: 10.4172/2155-6121.1000257

  Abstract PDF